UNC Lineberger Comprehensive Cancer Center

The method generates a Pocock-type boundary for repeated testing for toxicity (Ivanova et al., 2005).
1. Ivanova, A., Qaqish, B.F., and Schell, M.J. (2005). Continuous toxicity monitoring in phase II trials in oncology. Biometrics 61: 540-545.
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Maximum planned sample size:
The event probability (θ):
Desired probability of early stopping: