UNC Lineberger Comprehensive Cancer Center

This program generates Fleming's (Fleming, 1982) two-stage designs for Phase II single arm clinical trials that are admissible similar to Jung et al. (2004)

1. Fleming TR (1982). One-sample multiple testing procedure for phase II clinical trials. Biometrics 38: 143-151.
2. Jung SH, Lee TY, Kim KM, George S (2004). Admissible two-stage designs for phase II cancer clinical trials, Statistics in Medicine 23: 561-569.

Type I error rate, α (one-sided):
Response probability of poor drug, p0:
Response probability of good drug, p1: